microcrystalline cellulose msds fmc

10. April 2023 · by · in waverly city schools calendar

Learn about FMC's industry leading goal of net-zero emissions by 2035. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. MATERIAL SAFETY DATA SHEET. Find answers in our support articles. [FMC Study Number I92-1464]. MSDS Ref. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream All Rights Reserved. . *r_ *?~4$ &0Y# Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. } !1AQa"q2#BR$3br cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Product and Company Identification . Avicel RC-591 & CL-611 - Description. % Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Microcrystalline Cellulose; Cellulose; Functions. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. <> However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Are you sure you want to delete your template? {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Gloves, eye protection and a dust mask should be used. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Product Name Cellulose microcrystalline. Microcrystalline Cellulose E460 MSDS 1. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? 0.25 - 0.37. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Microcrystalline Cellulose (MCC) Manufacturing Industry. Earth Supplied Products LLC. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Watch Now. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. CAS #: 9004-34-6 Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. 2008-2023 ChemPoint. << Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Production of Pharmaceutical Grade Microcrystalline Cellulose. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Home. All Rights Reserved. : CL-611NF Date Approved: 01/13/2010. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. P}MFbN#[>r(y Report Category. Quantity: 1 700 kgs. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. % {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. The typical mean particle size is 20200 m. Watch Now. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. FMC, JRS and Mingtai were estimated to hold for . It is available in different grades and particle sizes. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. . We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. SUBSTANCE IDENTIFICATION 1.1. Synergies to simplify formulation challenges and reduce operational costs. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Heavy metals, % NMT 0.001 CAS #: 9004-34-6 . The table below shows the most common physicochemical parameters of this raw material. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. MATERIAL SAFETY DATA SHEET. Wu, K. Zuurman, H.W. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm <> ). Hi, let us know if you have any questions as you visit our website. /Contents 4 0 R ( For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Looking for FMC'searnings news? No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. ( Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. The most. : 9004-34-6 Date Approved: 01/31/2008 . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . 130. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Trademarks: Avicel PH-102. It is a white, free-flowing powder. Truly distinctive drug delivery solutions. Chemical Formula: (C6H10O5)n 1.4. Microcrystalline Cellulose / Avicel PH-102. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P CAS #: 9004-34-6 1.6. . However, it yields non-digestible fibre. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? CAS 9004-34-6, pH 5 - 7.5. Avicel PC 611 Microcrystalline Cellulose. Buy Chemicals. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Learn about FMC's differentiated biologically-based crop solutions. Chemical Formula: (C6H10O5)n 1.4. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Micro Crystalline Cellulose. By producing Avicel . w !1AQaq"2B #3Rbr United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. 1 0 obj Combines good flow and high compactibility. These grades have particle sizes ranging from <30 to approximately 200. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . SDS - Safety Data Sheet. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. xv}O2' H~KEe9>G/,:9\i Manufactured by: China . 4 0 obj ( Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Protect them from sunshine or rain. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. It is also inert and biocompatible. Well-recognized product that can do it all. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. /Resources 2 0 R We can send by Fedex, by ship or by plane according to international rules. 102331. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Document(s): certificate data msds. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. We know that our customers need to provide reliable and consistent products to their patients. A., and Smith, P. A. << Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Aqueous suspensions of microcrystalline cellulose have . Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Microcrystalline Cellulose (MCC) MSDS 1. 9,LL!z MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Molecular weight: Not Applicable 1.5. Thus, Avicel contributes no or very few calories to the food system. CoA. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. It is . AVICEL RC 581. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. PDF (2.77 mb) 2021 FMC Sustainability Report. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. 4. However, consumption of large quantities of the material may have a laxative effect. Test Data Available. Validity Area. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) If breathing is difficult or if . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. It . Avicel PH-101. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. POLYOX resins are nonionic polyethylene oxide solubility polymers. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . MCC helps in the formation of spheres because of its . 2021 Annual Report. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Performing this action will revert the following features to their default settings: Hooray! Revision No. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. No. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Cellulose microcrystalline for column chromatography. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. There may be more fiber in your food than you realized. Avicel Microcrystalline Cellulose Physical Properties. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Your file is uploaded and ready to be published. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Terms and Conditions Compliance Solutions Industries About 3E News & Events . Microcrystalline Cellulose Side Effects. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. INCI. Explore how we work and why we apply science and creativity for a better world to everything we do. Cellulose microcrystalline. 1 0 obj An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 4 0 obj If you are already a ChemPoint customer then sign up for access to our online ordering website. Avicel PC 611 (FMC Biopolymer) . endstream High performance lubricant that brings more to the tablet. LOT #: Available upon request. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). B;vLZpHU%ChUyD+[ Microcrystalline Cellulose / Avicel PH-102. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Remove %PDF-1.4 ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Magazine: Material safety data sheet - FMC Corporation. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Powder becomes slippery when wet. X\o^ Unique functionality for a broad range of pharmaceutical applications.

Harris Teeter Sushi Menu, Arrests In Bakersfield Last Night, Articles M